Bronchial Thermoplasty (BT) is a non-pharmacologic treatment for asthma that has been shown to result in significant improvements in a number of asthma control measures in three randomized clinical trials in patients with moderate-to-severe, persistent asthma. The Asthma Intervention Research 2 (AIR2) Trial, a double-blind, sham-controlled, randomized clinical trial of BT in patients with severe asthma, showed a 32% reduction in severe exacerbations, an 84% reduction in emergency room (ER) visits due to respiratory symptoms, and a 66% reduction in time lost from work/school/other daily activities due to asthma symptoms compared to a sham-treated group in the first year following the BT treatment period (day of first BT procedure until 6 weeks after the last bronchoscopy, approximately 12 weeks).